Multidimensional and multi-scale analysis of the rehabilitation after stroke

Neurorehabilitative therapy is the most effective treatment for promoting the recovery of motor deficits in stroke patients.
Nevertheless, the neural basis underlying the recovery associated with rehabilitative interventions is debated.
Here, we investigated the multiple facets of cortical remodeling induced by combined pharmacological and motor training rehabilitative therapy after stroke.
Using longitudinal imaging of cortical activity in the peri-infarct area during motor training, we demonstrated the progressive restoration of cortical motor maps and of cortical activity as assessed by calcium imaging.
The functional connectivity between the spared cortex and the injured hemisphere was reinforced by rehabilitation, as demonstrated by our simultaneous optogenetic and calcium imaging approach.
Additionally, two-photon microscopy revealed a significant increase in vascular density and the stabilization of peri-infarct area synaptic level circuitry following rehabilitation.
Finally, whole brain vasculature reconstruction with light sheet microscopy imaging on cleared tissues, reveals the effects of rehab on vasculature organization in the peri-lesioned area.
The present work, by combining imaging techniques and the manipulation of neuronal activity, provides the first in vivo evidence of the mechanism by which rehabilitation shapes cortical plasticity after stroke.

SCIENTIFIC COMMITTEE

  • Andrea Corvi, President, Università degli Studi di Firenze
  • Benedetto Allotta, Università degli Studi di Firenze
  • Pietro Caliandro, Università Cattolica del Sacro Cuore, Policlinico Gemelli, Roma
  • Isabella Campanini, AUSL Reggio Emilia
  • Federico Carpi, Università degli Studi di Firenze
  • Stefano Cavazza, Azienda Ospedaliero-Universitaria di Ferrara
  • Ugo Della Croce, Università degli Studi di Sassari
  • Silvia Fantozzi, Università degli Studi di Bologna
  • Maurizio Ferrarin, IRCCS Fondazione Don Carlo Gnocchi, Milano
  • Claudio Macchi, IRCCS Fondazione Don Carlo Gnocchi, Firenze
  • Antonio Nardone, IRCCS Fondazione Maugeri, Pavia
  • Francesco Saverio Pavone, Università degli Studi di Firenze
  • Dante Ronca, Seconda Università degli Studi di Napoli
  • Taian Vieira, Politecnico di Torino
  • Giuseppe Vannozzi, Università degli Studi di Roma “Foro Italico”

LOCAL ORGANIZING COMMITTEE

  • Federica Vannetti, IRCCS Fondazione Don Carlo Gnocchi
  • Francesco Esposito, Fondazione In Cammino, Università degli Studi di Firenze
  • Laura Fabbri, IRCCS Fondazione Don Carlo Gnocchi
  • Filippo Gerli, IRCCS Fondazione Don Carlo Gnocchi
  • Marco Freddolini, Fondazione In Cammino, Università degli Studi di Firenze
  • Sara Matteoli, Università degli Studi di Firenze
  • Silvia Pancani, IRCCS Fondazione Don Carlo Gnocchi
  • Guido Pasquini, IRCCS Fondazione Don Carlo Gnocchi

KEY DATES

  • March 2018: Call for Abstracts and Opening of Registrations
  • May, 15th 2018: Deadline for Abstract Submission
  • May, 31st 2018: New Deadline for Abstracts Submission!
  • June 30th 2018: Abstracts Acceptance Deadline
  • July 5th 2018New abstracts acceptance deadline!
  • July, 31th 2018: Deadline for Early Bird Registration
  • September, 21st 2018: Deadline for Registration
  • September, 26th 2018: NEW DEADLINE FOR REGISTRATION

ORGANIZING SECRETARIAT AND CME PROVIDER

MCO International Group S.r.l.
Via Luigi Carlo Farini, 11 – 50121 Firenze
Ph. + 39 055 2639073
Mob. + 39 353 3601321
alessandra.grossi@mcointernationalgroup.com
www.mcointernationalgroup.com

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